Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways.

@article{Jiang2013TamoxifenIM,
  title={Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways.},
  author={Meixiu Jiang and Ling Zhang and Xingzhe Ma and Wenquan Hu and Yuanli Chen and Miao Yu and Qixue Wang and Xiaoju Li and Zhinan Yin and Yan Zhu and Xiumei Gao and David P. Hajjar and Yajun Duan and Jihong Han},
  journal={The Biochemical journal},
  year={2013},
  volume={454 3},
  pages={467-77}
}
Macrophage adipocyte fatty acid-binding protein (FABP4) plays an important role in foam cell formation and development of atherosclerosis. Tamoxifen inhibits this disease process. In the present study, we determined whether the anti-atherogenic property of tamoxifen was related to its inhibition of macrophage FABP4 expression. We initially observed that tamoxifen inhibited macrophage/foam cell formation, but the inhibition was attenuated when FABP4 expression was selectively inhibited by siRNA… CONTINUE READING
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