Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells.

@article{Croxtall1994TamoxifenIG,
  title={Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells.},
  author={J. Croxtall and C. Emmas and J. White and Q. Choudhary and R. Flower},
  journal={Biochemical pharmacology},
  year={1994},
  volume={47 2},
  pages={
          197-202
        }
}
The non-steroidal anti-oestrogen tamoxifen inhibits proliferation of the A549 human lung adenocarcinoma cell line (EC50 congruent to 10 nM) yet there was no evidence of oestrogen receptor expression as determined by ligand binding assay and northern blotting. 17-beta-Oestradiol had no effect on A549 cell proliferation (1 pM-1 microM) and moreover a 100-fold excess failed to reverse the effect of 10 nM tamoxifen as did a 100-fold excess of the steroidal anti-oestrogens ICI 164384 and ICI 182780… Expand
Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer.
Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells
Effects of tamoxifen on human squamous cell carcinoma lines of the head and neck
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