Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients.

Abstract

Tamoxifen has been reported to potentiate the anticoagulant effect of warfarin and also to increase the plasma level of phenytoin, which are mainly metabolized by CYP2C9. The aim of this study was to determine the influence of tamoxifen on CYP2C9 activity in vivo in humans. Thirteen breast cancer patients who would start tamoxifen following cytotoxic… (More)

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@article{Boruban2006TamoxifenIC, title={Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients.}, author={Melih Cem Boruban and U. Yasar and Mehmet Babaoğlu and Orhan Sencan and A. Bozkurt}, journal={Journal of chemotherapy}, year={2006}, volume={18 4}, pages={421-4} }