Tamoxifen inhibits Ca2+ uptake by the cardiac sarcoplasmic reticulum

@article{Kargacin2000TamoxifenIC,
  title={Tamoxifen inhibits Ca2+ uptake by the cardiac sarcoplasmic reticulum},
  author={M. E. Kargacin and Z. Ali and C. A. Ward and N. S. Pollock and G. Kargacin},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={440},
  pages={573-579}
}
Abstract. Ca2+ transients in isolated cardiac ventricular myocytes and the amount of Ca2+ that could be released from the sarcoplasmic reticulum (SR) in these cells by caffeine were reduced in the presence of tamoxifen. To examine the effects of tamoxifen on the cardiac muscle SR directly, isolated SR vesicles and fluorimetry methods were used to measure the uptake of Ca2+ by the SR and the ATPase activity of the SR Ca2+ pump. SR Ca2+ uptake was inhibited by tamoxifen at concentrations greater… Expand
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