Tamoxifen-induced estrogen receptor up-regulation in mammary tumor cells is not related to growth inhibition


 Treatment of estrogen receptor (ER)-positive mammary tumors with tamoxifen produces a dramatic accumulation of ER in the cell nucleus. We investigated whether this phenomenon might be related to the antitumor activity of the drug. Five tamoxifen derivatives for which an influence on MCF-7 cell growth had previously been established were tested for that… (More)
DOI: 10.1007/s002800050587


2 Figures and Tables