Tamoxifen-induced cell death in malignant melanoma cells: possible involvement of the insulin-like growth factor-1 (IGF-1) pathway

@article{KanterLewensohn2000TamoxifeninducedCD,
  title={Tamoxifen-induced cell death in malignant melanoma cells: possible involvement of the insulin-like growth factor-1 (IGF-1) pathway},
  author={Lena Kanter-Lewensohn and L Girnita and A Girnita and Anica Dricu and Gunilla Olsson and L Leech and Gunnar P Nilsson and Agneta M Hilding and Johan Wejde and Kerstin Brismar and Olle Larsson},
  journal={Molecular and Cellular Endocrinology},
  year={2000},
  volume={165},
  pages={131-137}
}
Recent data indicate that the estrogen receptor (ER) blocker tamoxifen (TAM) can induce cell death in malignant melanoma cells. However, as shown in the present study and several other studies melanoma cells usually do not express classical ERs. In the present study we investigated whether the cytotoxic effect of TAM on melanoma cells could depend on interference with the expression or function of the insulin-like growth factor-1 receptor (IGF-1R), a plasma membrane receptor important for cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 citations