Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial

@article{Fisher1999TamoxifenIT,
  title={Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial},
  author={Bernard J Fisher and James Dignam and Norman Wolmark and Donald Lawrence Wickerham and Robert H. Oishi},
  journal={The Lancet},
  year={1999},
  volume={353},
  pages={1993-2000}
}
BACKGROUND We have shown previously that lumpectomy with radiation therapy was more effective than lumpectomy alone for the treatment of ductal carcinoma in situ (DCIS). We did a double-blind randomised controlled trial to find out whether lumpectomy, radiation therapy, and tamoxifen was of more benefit than lumpectomy and radiation therapy alone for DCIS. METHODS 1804 women with DCIS, including those whose resected sample margins were involved with tumour, were randomly assigned lumpectomy… CONTINUE READING
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