Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.

@article{Karimian2008TamoxifenIB,
  title={Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.},
  author={Elham Karimian and Andrei S Chagin and Jennifer Gjerde and Terhi Heino and Ernst Asbjorn Lien and C Ohlsson and Lars S{\"a}vendahl},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 8},
  pages={1267-77}
}
Tamoxifen (Tam) has been used experimentally to treat boys with gynecomastia and girls with McCune-Albright syndrome. This drug was recently shown to inhibit the growth of cultured fetal rat metatarsal bones and thus might also affect bone growth in vivo. Four-week-old Sprague-Dawley rats were gavaged daily with vehicle alone (peanut oil), Tam (40 mg/kg/d… CONTINUE READING