Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study.

@article{Fisher2005TamoxifenFT,
  title={Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study.},
  author={Bernard Fisher and J. P. Costantino and Donald Lawrence Wickerham and Reena S. Cecchini and Walter M. Cronin and Andr{\'e} Robidoux and Therese Bartholomew Bevers and Maureen T Kavanah and James Norman Atkins and Richard G. Margolese and Carolyn D. Runowicz and Joan M James and Leslie G. Ford and Norman Wolmark},
  journal={Journal of the National Cancer Institute},
  year={2005},
  volume={97 22},
  pages={1652-62}
}
BACKGROUND Initial findings from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (P-1) demonstrated that tamoxifen reduced the risk of estrogen receptor-positive tumors and osteoporotic fractures in women at increased risk for breast cancer. Side effects of varying clinical significance were observed. The trial was unblinded because of the positive results, and follow-up continued. This report updates our initial findings. METHODS Women (n = 13,388) were… CONTINUE READING
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Side effect with tamoxifen and solutions with aromatase inhibiters

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  • Eur J Cancer Supp
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