Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.

@article{Fisher1998TamoxifenFP,
  title={Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.},
  author={Bernadette Fisher and J. P. Costantino and Donald Lawrence Wickerham and Carol K. Redmond and Maureen T Kavanah and Walter M. Cronin and Vitali Vogel and Andr{\'e} Robidoux and Nickolai Dimitrov and Jacqueline Atkins and Mary B Daly and Samuel Wieand and Elizabeth Tan-chiu and L Ford and Norman Wolmark},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 18},
  pages={1371-88}
}
BACKGROUND The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that the drug might play a role in breast cancer prevention. To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992. METHODS Women (N=13388) at increased risk for breast cancer because they 1) were 60 years of age or older, 2) were 35-59 years of age with a 5… CONTINUE READING
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