Tamoxifen eliminates estrogen’s neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system

@article{Dluzen2001TamoxifenEE,
  title={Tamoxifen eliminates estrogen’s neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system},
  author={Dean E. Dluzen and Janet L. Mcdermott and Linda I. Anderson},
  journal={Neurotoxicity Research},
  year={2001},
  volume={3},
  pages={291-300}
}
The capacity for 17-a and 17-B estradiol to modulate MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system and potential antagonism of this modulation by the anti-estrogen, tamoxifen, were evaluated. Treatment of retired breeder ovariect-omized C57/BI mice with17-B estradiol diminished the amount of striatal dopamine reduction resulting from MPTP treatment with striatal dopamine concentrations of these17-B estradiol treated mice failing to differ significantly from vehicle treated… CONTINUE READING

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