Tamoxifen citrate loaded amphiphilic beta-cyclodextrin nanoparticles: in vitro characterization and cytotoxicity.

@article{MemisogluBilensoy2005TamoxifenCL,
  title={Tamoxifen citrate loaded amphiphilic beta-cyclodextrin nanoparticles: in vitro characterization and cytotoxicity.},
  author={Erem Memisoglu-Bilensoy and Imran Vural and Am{\'e}lie Bochot and Jack Michel Renoir and Dominique Duch{\^e}ne and A. Atill{\^a} Hincal},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={104 3},
  pages={489-96}
}
Nanospheres and nanocapsules of beta-CDC6, amphiphilic beta-cyclodextrin modified on the secondary face with 6C aliphatic esters, were prepared with nanoprecipitation technique directly from inclusion complexes of tamoxifen citrate and beta-CDC6 (1:1 molar ratio). Blank and loaded nanospheres and nanocapsules were characterized by particle size distribution, zeta potential, drug loading and in vitro drug release. Particle sizes were between 250 and 300 nm for different formulations of… CONTINUE READING

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