Tamoxifen as adjuvant therapy in breast cancer. Current status.

  title={Tamoxifen as adjuvant therapy in breast cancer. Current status.},
  author={Piers Nicholas Plowman},
  volume={46 5},
Tamoxifen retains its place as the most important drug in the management of human breast cancer. As time passes, it becomes clear that this drug is no longer to be regarded as a simple antiestrogen, since it modifies other cellular signalling mechanisms, giving scientific credence to the growth inhibitory effects observed in estrogen receptor-negative tumours. With the role of tamoxifen in breast cancer being well documented, recent interest has concentrated on its now proven efficacy in… CONTINUE READING