Tamoxifen and oestrogen both protect the rat muscle against physiological damage

@article{Koot1991TamoxifenAO,
  title={Tamoxifen and oestrogen both protect the rat muscle against physiological damage},
  author={R. W. Koot and G. J. Amelink and M. Blankenstein and P. R. B{\"a}r},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1991},
  volume={40},
  pages={689-IN10}
}
Tamoxifen (TX), an oestrogen antagonist, was used to characterize the protective effect of oestradiol (E2) on exercise-related creatine kinase (CK) release from skeletal muscle of the rat. Subcutaneous administration of TX for 3 weeks in female rats had a profound antioestrogen effect as evidenced by a reduced weight of the uterus. The CK release after electrical stimulation of the isolated soleus muscle, previously shown to be E2-dependent, was markedly reduced (30-50%) after treatment with TX… Expand
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