Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer.

@article{Fisher1997TamoxifenAC,
  title={Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer.},
  author={Bernard Fisher and James Dignam and Norman Wolmark and Arthur P Decillis and Birol Emir and Donald Lawrence Wickerham and John Bryant and Nikolay V. Dimitrov and Neil Abramson and James Norman Atkins and H R Shibata and Luc Desch{\^e}nes and Richard G. Margolese},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 22},
  pages={1673-82}
}
BACKGROUND The B-20 study of the National Surgical Adjuvant Breast and Bowel Project (NSABP) was conducted to determine whether chemotherapy plus tamoxifen would be of greater benefit than tamoxifen alone in the treatment of patients with axillary lymph node-negative, estrogen receptor-positive breast cancer. METHODS Eligible patients (n = 2306) were randomly assigned to one of three treatment groups following surgery. A total of 771 patients with follow-up data received tamoxifen alone; 767… CONTINUE READING

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A randomized clinical trial evaluating sequential methotrexate and fluorouracil in the treatment of patients with node - negative breast cancer who have estrogen - receptor - negative tumors

  • B Fisher, J Costantino, C Redmond, R Poisson, D Bowman, J Couture
  • N Engl J Med
  • 1989

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node - negative breast cancer who have estrogen - receptor - positive tumors

  • B Fisher, J Dignam, EP Mamounas, JP Costantino, DL Wickerham
  • N Engl J Med
  • 1989

methotrexate and fluorouracil in the treatment of patients with nodenegative breast cancer who have estrogen-receptor-negative tumors

  • B Fisher, J Costantino, C Redmond, R Poisson, D Bowman, J Couture
  • N Engl J Med 1989;320:473–8
  • 1989

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