Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial.

@article{King2001TamoxifenAB,
  title={Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial.},
  author={Mary-Claire King and Samuel Wieand and Kathryn Azelia Hale and Myoungkeun Lee and Thomas Walsh and Kirk Owens and John Tait and Leslie P. Ford and Barbara K. Dunn and J. P. Costantino and Lawrence Wickerham and Norman Wolmark and Barbara A Fisher},
  journal={JAMA},
  year={2001},
  volume={286 18},
  pages={2251-6}
}
CONTEXT Among cancer-free women aged 35 years or older, tamoxifen reduced the incidence of estrogen receptor (ER)-positive but not ER-negative breast cancer. The effect of tamoxifen on breast cancer incidence among women at extremely high risk due to inherited BRCA1 or BRCA2 mutations is unknown. OBJECTIVE To evaluate the effect of tamoxifen on incidence of breast cancer among cancer-free women with inherited BRCA1 or BRCA2 mutations. DESIGN, SETTING, AND PARTICIPANTS Genomic analysis of… CONTINUE READING

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