Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells

@article{Lagadec2008TamoxifenAT,
  title={Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells},
  author={Chann Lagadec and Eric Adriaenssens and R. A. Toillon and Val{\'e}rie Chopin and Rodrigue Romon and F. Van Coppenolle and H Hondermarck and Xuefen Le Bourhis},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={1472-1477}
}
Tamoxifen (TAM), is widely used as a single agent in adjuvant treatment of breast cancer. Here, we investigated the effects of TAM in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in estrogen receptor-α (ER-α)-positive and -negative breast cancer cells. We showed that cotreatment with TAM and TRAIL synergistically induced apoptosis regardless of ER-α status. By contrast, cotreatment did not affect the viability of normal breast epithelial cells. Cotreatment… CONTINUE READING

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