Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor α-mediated transforming growth factor-β1/Smad signaling pathway.

@article{Kim2014TamoxifenAR,
  title={Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor α-mediated transforming growth factor-β1/Smad signaling pathway.},
  author={Dal Kim and Ae Sin Lee and Yu Jin Jung and Kyoung Hee Yang and Sik Lee and Sung Kwang Park and Won Kim and Kyung Pyo Kang},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2014},
  volume={29 11},
  pages={2043-53}
}
BACKGROUND After insult to the kidney, a renal fibrotic process is initiated with sustained inflammation, fibroblast activation and accumulation of extracellular matrix (ECM). Tamoxifen has been used as an anti-estrogen for the prevention and treatment of breast cancer. In this study, we investigated the protective effects of tamoxifen on unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis and its molecular mechanism. METHODS Renal fibrosis was induced by UUO in 7… CONTINUE READING
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Cellular and molecular mechanisms of renal fibrosis

  • Y. Liu
  • Nat Rev Nephrol 2011;
  • 2011
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