Corpus ID: 195414850

Tamoxifen Pharmacogenetics: CYP2D6 and Other Variables Influencing Tamoxifen and Tamoxifen Metabolite Exposure

@inproceedings{Tchu2013TamoxifenPC,
  title={Tamoxifen Pharmacogenetics: CYP2D6 and Other Variables Influencing Tamoxifen and Tamoxifen Metabolite Exposure},
  author={S. Tchu},
  year={2013}
}
  • S. Tchu
  • Published 2013
  • Medicine
  • Author(s): Tchu, Simone Ming | Advisor(s): Wu, Alan HB | Abstract: Tamoxifen is a selective estrogen receptor modulator (SERM) that is used for the treatment of estrogen receptor positive (ER+) breast cancer, most commonly as an adjuvant for the prevention of disease recurrence. Several retrospective studies suggest that functional CYP2D6 polymorphisms are associated with the clinical outcome of tamoxifen adjuvant therapy; variants that confer reduced enzymatic activity are associated with… CONTINUE READING