Tamoxifen Modulation of Etoposide Cytotoxicity Involves Inhibition of Protein Kinase C Activity and Insulin-Like Growth Factor II Expression in Brain Tumor Cells

@article{Ramachandran2004TamoxifenMO,
  title={Tamoxifen Modulation of Etoposide Cytotoxicity Involves Inhibition of Protein Kinase C Activity and Insulin-Like Growth Factor II Expression in Brain Tumor Cells},
  author={Cheppail Ramachandran and Ziad El Khatib and Athena Pefkarou and John G. Fort and Hugo B. Fonseca and Steven J. Melnick and Enrique A Escalon},
  journal={Journal of Neuro-Oncology},
  year={2004},
  volume={67},
  pages={19-28}
}
Tamoxifen, a non-steroidal anti-estrogen widely used against breast cancer, is also useful for treatment of other malignancies, due to its sensitizing effect on other chemotherapeutic agents and radiation. We have investigated the advantages of combining tamoxifen with one of the commonly used cancer chemotherapeutic drug, etoposide (VP-16) in brain tumor cell lines. While tamoxifen (10 uM) increased etoposide cytotoxicity 8.3-fold in the human glioma cell line (HTB-14), it increased etoposide… CONTINUE READING

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