Tamoxifen Modulates Protein Kinase C via Oxidative Stress in Estrogen Receptor-negative Breast Cancer Cells*

@article{Gundimeda1996TamoxifenMP,
  title={Tamoxifen Modulates Protein Kinase C via Oxidative Stress in Estrogen Receptor-negative Breast Cancer Cells*},
  author={U. Gundimeda and Z. Chen and R. Gopalakrishna},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={13504 - 13514}
}
Nonsteroidal agent tamoxifen (Tam), a therapeutic/chemopreventive agent for breast cancer, inhibits protein kinase C (PKC), which is considered to be one of its extra-estrogen receptor sites of action. This drug is required at higher (>100 μM) concentrations to inhibit PKC in the test tube, whereas it is required at lower (1-10 μM) concentrations to induce inhibition of cell growth in estrogen receptor-negative cell types. To identify additional mechanisms of action of Tam on PKC and cell… Expand
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