Tamoxifen Induces Short-Term Cumulative DNA Damage and Liver Tumors in Rats: Promotion by Phénobarbital

Abstract

Tamoxifen administered in the diet (420 ppm) to Wistar rats (TOX:P) for only 3 months caused cumulative hepatic DNA damage as assessed by 32P-postlabeling, consistent with the proposal that tamoxifen is a genotoxic carcinogen in this species. Promotion of tumor development with phéno barbital after discontinuation of dietary tamoxifen resulted in the forma… (More)

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