Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats

@article{Karimian2008TamoxifenIB,
  title={Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats},
  author={E. Karimian and A. Chagin and J. Gjerde and T. Heino and E. Lien and C. Ohlsson and L. S{\"a}vendahl},
  journal={Journal of Bone and Mineral Research},
  year={2008},
  volume={23}
}
  • E. Karimian, A. Chagin, +4 authors L. Sävendahl
  • Published 2008
  • Biology, Medicine
  • Journal of Bone and Mineral Research
  • Tamoxifen (Tam) has been used experimentally to treat boys with gynecomastia and girls with McCune‐Albright syndrome. This drug was recently shown to inhibit the growth of cultured fetal rat metatarsal bones and thus might also affect bone growth in vivo. Four‐week‐old Sprague‐Dawley rats were gavaged daily with vehicle alone (peanut oil), Tam (40 mg/kg/d; 1 or 4 wk), or estradiol (40 μg/kg/d; 4 wk). Five of the 10 rats in each group were killed after 4 wk and the other five after 14 wk of… CONTINUE READING
    28 Citations
    Resveratrol Treatment Delays Growth Plate Fusion and Improves Bone Growth in Female Rabbits
    • 9
    • PDF
    Regulation of bone growth via ligand-specific activation of estrogen receptor alpha.
    • 12
    • PDF
    Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones.
    • 42
    • PDF
    EFFECT OF SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) ON GROWTH PLATE CARTILAGE
    • 1
    Skeletal and Uterotrophic Effects of Endoxifen in Female Rats
    • 1
    • PDF
    Assessment of a nonsteroidal aromatase inhibitor, letrozole, in juvenile rats.
    • 8
    Antifibrotic effect of tamoxifen in a model of progressive renal disease.
    • 58
    • PDF
    Estrogen signaling in growth plate cartilage.
    • 10
    • PDF

    References

    SHOWING 1-10 OF 49 REFERENCES
    The Effect of Tamoxifen on Bone Metabolism and Skeletal Growth is Different in Ovariectomized and Intact Rats
    • 15
    Tamoxifen stimulates cancellous bone formation in long bones of female mice.
    • 24
    • PDF
    Effects of estrogen on growth plate senescence and epiphyseal fusion
    • 262
    • PDF
    Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes.
    • 101
    • PDF
    Raloxifene acts as an estrogen agonist on the rabbit growth plate.
    • 28
    • PDF
    The role of estrogen in bone growth and maturation during childhood and adolescence
    • G. Cutler
    • Biology, Medicine
    • The Journal of Steroid Biochemistry and Molecular Biology
    • 1997
    • 199
    Preliminary in situ identification of estrogen target cells in bone
    • 107