Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats

@article{Karimian2008TamoxifenIB,
  title={Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats},
  author={Elham Karimian and Andrei S. Chagin and Jennifer Gjerde and Terhi J. Heino and Ernst Asbj{\o}rn Lien and Claes Ohlsson and Lars S{\"a}vendahl},
  journal={Journal of Bone and Mineral Research},
  year={2008},
  volume={23}
}
Tamoxifen (Tam) has been used experimentally to treat boys with gynecomastia and girls with McCune‐Albright syndrome. This drug was recently shown to inhibit the growth of cultured fetal rat metatarsal bones and thus might also affect bone growth in vivo. Four‐week‐old Sprague‐Dawley rats were gavaged daily with vehicle alone (peanut oil), Tam (40 mg/kg/d; 1 or 4 wk), or estradiol (40 μg/kg/d; 4 wk). Five of the 10 rats in each group were killed after 4 wk and the other five after 14 wk of… 

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References

SHOWING 1-10 OF 49 REFERENCES

The Effect of Tamoxifen on Bone Metabolism and Skeletal Growth is Different in Ovariectomized and Intact Rats

TLDR
The findings indicate that TAM exerts an effect of estrogen agonist on bone metabolism and skeletal growth in OVX rats, however, it does not affect them in intact rats.

Tamoxifen stimulates cancellous bone formation in long bones of female mice.

Selective estrogen receptor modulators (SERMs) have been developed as a means of targeting estrogen's protective effect on the skeleton in the treatment of postmenopausal osteoporosis. Although it is

17 beta-estradiol stimulates cancellous bone formation in female rats.

TLDR
Results suggest that stimulation of cancellous bone formation is a physiological action of E2 in the rat, and Stimulation of bone formation by estrogen showed a similar pattern of dose-responsiveness to recognized physiological targets of E1: suppression of longitudinal growth and uterine growth.

Effects of estrogen on growth plate senescence and epiphyseal fusion

TLDR
The data suggest that epiphyseal fusion is triggered when the proliferative potential of growth plate chondrocytes is exhausted; and estrogen accelerates the programmed senescence of the growth plate, thus causing earlier proliferative exhaustion and consequently earlier fusion.

Raloxifene acts as an estrogen agonist on the rabbit growth plate.

TLDR
It is concluded that raloxifene acts as an estrogen agonist on the growth plate, accelerating growth plate senescence and thus hastening epiphyseal fusion.

Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes.

TLDR
It is concluded that apoptosis is one mechanism involved in growth retardation induced by glucocorticoids, and premature loss of resting/proliferative chondrocytes by apoptosis could contribute to incomplete catch-up seen after prolonged glucoc Corticoid treatment.

Comparison of tamoxifen and testosterone propionate in male rats: differential prevention of orchidectomy effects on sex organs, bone mass, growth, and the growth hormone-IGF-I axis.

TLDR
Tamoxifen prevented ORX effects on bone and cholesterol in male rats without affecting sex organs or PRL and might be useful for men who must avoid androgens.

Preliminary in situ identification of estrogen target cells in bone

TLDR
It is suggested that osteocytes are major skeletal estrogen target cells and may be involved in coordinating the response of surface bone cells to the hormone, and further that chondrocytes may beinvolved in estrogen‐induced epiphyseal growth plate fusion.

The role of estrogen in bone growth and maturation during childhood and adolescence

  • G. Cutler
  • Medicine, Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 1997