Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats

  title={Tamoxifen Impairs Both Longitudinal and Cortical Bone Growth in Young Male Rats},
  author={E. Karimian and A. Chagin and J. Gjerde and T. Heino and E. Lien and C. Ohlsson and L. S{\"a}vendahl},
  journal={Journal of Bone and Mineral Research},
  • E. Karimian, A. Chagin, +4 authors L. Sävendahl
  • Published 2008
  • Biology, Medicine
  • Journal of Bone and Mineral Research
  • Tamoxifen (Tam) has been used experimentally to treat boys with gynecomastia and girls with McCune‐Albright syndrome. This drug was recently shown to inhibit the growth of cultured fetal rat metatarsal bones and thus might also affect bone growth in vivo. Four‐week‐old Sprague‐Dawley rats were gavaged daily with vehicle alone (peanut oil), Tam (40 mg/kg/d; 1 or 4 wk), or estradiol (40 μg/kg/d; 4 wk). Five of the 10 rats in each group were killed after 4 wk and the other five after 14 wk of… CONTINUE READING
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