Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances.

@article{Wiseman1994TamoxifenNM,
  title={Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances.},
  author={H. Wiseman},
  journal={Trends in pharmacological sciences},
  year={1994},
  volume={15 3},
  pages={
          83-9
        }
}
  • H. Wiseman
  • Published 1994
  • Biology, Medicine
  • Trends in pharmacological sciences
Tamoxifen protects membranes and lipoprotein particles against oxidative damage. This antioxidant action is likely to contribute to the observed cardioprotective action of tamoxifen and supports the use of this compound in treating and even preventing breast cancer. Membrane-mediated mechanisms of tamoxifen action, through a putative modulation of membrane fluidity, are likely to play an important role in its anticancer action and its ability to reverse multidrug resistance, and could also lead… Expand
Tamoxifen and estrogens as membrane antioxidants: comparison with cholesterol.
  • H. Wiseman
  • Chemistry, Medicine
  • Methods in enzymology
  • 1994
Mechanisms of Estrogenic Protection against gp120-Induced Neurotoxicity
Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications.
Effects of tamoxifen on the electron transport chain of isolated rat liver mitochondria
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