Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials

  title={Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials},
  author={Ali Talaei and Meysam Pourgholami and Hoda Khatibi-Moghadam and Farhad Faridhosseini and Fatemeh Farhoudi and Arash Askari-Noghani and Ramin Sadeghi},
  journal={Journal of Clinical Psychopharmacology},
Objective The aim of this study was to conduct a systematic review of literature to retrieve all randomized controlled trials that evaluated the efficacy of tamoxifen on manic mood episodes and meta-analyze their quantitative results. Methods Four electronic databases were systematically searched from their inception to March 2014: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials), Scopus, and PsychINFO. Pooled difference in means of changes in mania scores and pooled… 

Tamoxifen for bipolar disorder: Systematic review and meta-analysis

Tamoxifen appears to be a promising potential treatment for episodes of mania, and future studies could investigate its effects as an adjunct to dopamine antagonists for improved anti-manic efficacy, and establish its longer term effects on mood, particularly depression and relapse.

Prescribing Tamoxifen in Patients With Mood Disorders

Patients with a history of mood disorders may require a close clinical surveillance during tamoxifen use, and the use of tamoxIFen as an antimanic agent in psychiatric settings requires caution, as available evidence came from small-sample studies with short observation time.

The efficacy of psychotherapies and pharmacotherapies for mental disorders in adults: an umbrella review and meta‐analytic evaluation of recent meta‐analyses

After more than half a century of research, thousands of RCTs and millions of invested funds, the effect sizes of psychotherapy and pharmacotherapies for mental disorders are limited, suggesting a ceiling effect for treatment research as presently conducted.

Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders

  • M. Khan
  • Psychology, Medicine
    International journal of endocrinology
  • 2018
Results together with potent neurocognitive, neuroprotective, and cardiometabolic properties suggest that selective estrogen receptor modulators (SERMs) could be the potential targets for designing effective and safer therapies for psychiatric disorders.

Slim and Euthymic Tamoxifen and Aripiprazole in Bipolar Disorder: A Case Report.

A case of a bipolar patient who initiated tamoxifen after a breast cancer diagnosis is reported, aiming to highlight the hypothesized positive impact of tamoxIFen on the progression of the disorder and a possible combination therapy with aripiprazole.

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

The current understanding identifies the PKC pathway as a potential therapeutic avenue for BD and presents recent advances from preclinical and clinical studies that further support the role of PKC.

Pharmacological treatment of adult bipolar disorder

We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled

Long-term effectiveness and safety of endoxifen in the treatment of bipolar mania: a case report

  • Vaibhav Dubey
  • Medicine, Psychology
    International Journal of Advances in Medicine
  • 2022
This case showed the long-term effectiveness and safety of high-dose endoxifen to control mania in a patient with BD, and increased alcohol consumption administered endoxIFen 8 mg BID for a period of 3-months, to achieve a better response.

Existing and emerging pharmacological approaches to the treatment of mania: A critical overview

Manic episodes are a defining, frequent and dramatically disabling occurrence in the course of Bipolar Disorder type I. Current pharmacotherapy of mania lists a good number of agents, but differences

Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

The in vitro, in vivo, and mechanistic studies of the anti-infective activity of tamoxifen, toremifene, clomiphene, and their analogs are reviewed and the pharmacologic properties of this privileged scaffold are discussed and its potential utility in treating infectious diseases is discussed.



Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study.

Investigating whether antimanic effects can be achieved with a protein kinase C inhibitor in subjects with mania found that it significantly decreased manic symptoms within a short period of time and showed significant improvement in mania.

Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen.

Tamoxifen demonstrated antimanic properties and was remarkably well tolerated, and the findings encourage further clarification of the role of PKC in the pathophysiologic mechanism of bipolar I disorder and development of novel anti-PKC agents as potentialantimanic or mood-stabilizing agents.

A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania

A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder

Protein Kinase C Inhibitors: Rationale for Use and Potential in the Treatment of Bipolar Disorder

A growing body of work both on a preclinical and clinical level indicates that PKC signalling may play an important role in the pathophysiology and treatment of bipolar disorder, and the development of CNS-penetrant PKC inhibitors may have considerable benefit for this devastating illness.

Clinical recognition and management of depression in node negative breast cancer patients treated with tamoxifen

It is concluded that clinical depression as a side effect of tamoxifen therapy may be more common than previously believed and should be further rigorously investigated to confirm or deny the clinical impressions.

Tamoxifen in the treatment of breast cancer.

  • S. Legha
  • Medicine, Biology
    Annals of internal medicine
  • 1988
A significant increase in the disease-free survival of postmenopausal women treated with tamoxifen is shown, particularly in patients with hormone-receptor-positive tumors.

Successful Combined Therapy with Tamoxifen and Lithium in a Paradoxical Sleep Deprivation‐Induced Mania Model

The findings suggest that lithium and tamoxifen exert reversal effects against PSD‐induced hyperactivity in mice and provides support for an alternative treatment of individuals who either do not respond adequately or cannot tolerate the adverse effects associated with therapeutic doses of lithium.

Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta‐analysis of randomized placebo‐controlled trials

The aim of this research was to perform a systematic review to identify all randomized controlled trials (RCTs) evaluating the efficacy and safety of add‐on celecoxib for treatment of depressive mood