Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials

@article{Talaei2016TamoxifenAP,
  title={Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials},
  author={A. Talaei and M. Pourgholami and H. Khatibi-Moghadam and Farhad Faridhosseini and F. Farhoudi and Arash Askari-Noghani and R. Sadeghi},
  journal={Journal of Clinical Psychopharmacology},
  year={2016},
  volume={36},
  pages={272–275}
}
  • A. Talaei, M. Pourgholami, +4 authors R. Sadeghi
  • Published 2016
  • Medicine
  • Journal of Clinical Psychopharmacology
  • Objective The aim of this study was to conduct a systematic review of literature to retrieve all randomized controlled trials that evaluated the efficacy of tamoxifen on manic mood episodes and meta-analyze their quantitative results. Methods Four electronic databases were systematically searched from their inception to March 2014: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials), Scopus, and PsychINFO. Pooled difference in means of changes in mania scores and pooled… CONTINUE READING
    20 Citations

    Topics from this paper.

    Tamoxifen for bipolar disorder: Systematic review and meta-analysis
    • 4
    Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders
    • M. M. Khan
    • Medicine
    • International journal of endocrinology
    • 2018
    • 7
    • PDF
    Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature
    • 23
    Pharmacological treatment of adult bipolar disorder
    • 39
    How promising is neuroactive steroid drug discovery?
    • 2
    Tamoxifen and amphetamine abuse: Are there therapeutic possibilities?
    • 13
    Hormonal Treatments for Major Depressive Disorder: State of the Art.

    References

    SHOWING 1-10 OF 18 REFERENCES
    Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study.
    • 168
    • Highly Influential
    • PDF
    Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen.
    • 170
    • PDF
    A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania
    • 20
    Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania.
    • 75
    A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder
    • 100
    Clinical recognition and management of depression in node negative breast cancer patients treated with tamoxifen
    • 47
    Tamoxifen in the treatment of breast cancer.
    • S. Legha
    • Medicine
    • Annals of internal medicine
    • 1988
    • 380
    Successful Combined Therapy with Tamoxifen and Lithium in a Paradoxical Sleep Deprivation‐Induced Mania Model
    • 37