Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex

@article{Phillis1998TamoxifenAC,
  title={Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex},
  author={J. Phillis and D. Song and M. O'regan},
  journal={Brain Research},
  year={1998},
  volume={780},
  pages={352-355}
}
The effects of the anti-estrogen, anion channel blocker, tamoxifen on amino acid release from the ischemic rat cerebral cortex was investigated using a cortical cup technique. Tamoxifen (20 microM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia-evoked efflux of aspartate, glutamate, taurine and phosphoethanolamine. Reductions in the ischemia-evoked levels of these amino acids suggest that tamoxifen may attenuate chloride-related osmotic cell swelling and the… Expand
Effects of Anion Channel Blockers on Hyposmotically Induced Amino Acid Release From the In Vivo Rat Cerebral Cortex
Characterization of Endogenous Amino Acid Efflux from Hippocampal Slices during Chemically-Induced Ischemia
Release of l-aspartate by reversal of glutamate transporters
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
The neurotoxicity of excitatory amino acids is produced by passive chloride influx
  • S. Rothman
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1985
Glial swelling in ischemia: a hypothesis.
...
1
2
3
...