Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis.

Abstract

PURPOSE Proteus mirabilis is a common cause of urinary tract infection. We determined the role of Tamm-Horsfall protein as a host defense factor against the cystitis and pyelonephritis caused by P. mirabilis. MATERIALS AND METHODS We generated Tamm-Horsfall protein gene knockout mice using homologous recombination. We introduced P. mirabilis… (More)
DOI: 10.1016/j.juro.2009.01.014

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