Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

@article{Micanovic2015TammHorsfallPR,
  title={Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.},
  author={Radmila Micanovic and Brahmananda Chitteti and Pierre C Dagher and Edward F Srour and Shehnaz Khan and Takashi Hato and Allison Lyle and Yan Tong and Xue-Ru Wu and Tarek M El-Achkar},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2015},
  volume={26 9},
  pages={2172-82}
}
Tamm-Horsfall protein (THP) is a glycoprotein uniquely expressed in the kidney. We recently showed an important role for THP in mediating tubular cross-talk in the outer medulla and in suppressing neutrophil infiltration after kidney injury. However, it remains unclear whether THP has a broader role in neutrophil homeostasis. In this study, we show that THP deficiency in mice increases the number of neutrophils, not only in the kidney but also in the circulation and in the liver, through… CONTINUE READING
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