Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo.

  title={Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo.},
  author={Eric O'Neill and Walter Kolch},
  journal={Cell cycle},
  volume={4 3},
The Raf-1 kinase has a well established role in activating the MEK-ERK/MAPK pathway. However, accumulating evidence including the phenotype of Raf-1(-/-) mice suggested that Raf-1 may have other functions independent of its role as MEK activator, in particular pertaining to protection against apoptosis. We have recently demonstrated a new role of Raf-1 by showing that Raf-1 controls the proapoptotic kinase MST2/Hippo. In mammalian cells MST2 is activated by stress signals and causes apoptosis… CONTINUE READING
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