Taming platelets with cyclic nucleotides.

  title={Taming platelets with cyclic nucleotides.},
  author={Ulrike R Schwarz and Ulrich Walter and Martin Eigenthaler},
  journal={Biochemical pharmacology},
  volume={62 9},
Cardiovascular diseases are often accompanied and aggravated by pathologic platelet activation. Tight regulation of platelet function is an essential prerequisite for intact vessel physiology or effective cardiovascular therapy. Physiological platelet antagonists as well as various pharmacological vasodilators inhibit platelet function by activating adenylyl and guanylyl cyclases and increasing intracellular cyclic AMP (cAMP) and cyclic GMP (cGMP) levels, respectively. Elevation of platelet… CONTINUE READING