Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis.

@article{Reginato2011TamingOT,
  title={Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis.},
  author={Silvia Reginato and Roberto Giann{\'i}-Barrera and Andrea Banfi},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 6},
  pages={1654-8}
}
VEGF (vascular endothelial growth factor) is the master regulator of blood vessel growth. However, it displayed substantial limitations when delivered as a single gene to restore blood flow in ischaemic conditions. Indeed, uncontrolled VEGF expression can easily induce aberrant vascular structures, and short-term expression leads to unstable vessels. Targeting the second stage of the angiogenic process, i.e. vascular maturation, is an attractive strategy to induce stable and functional vessels… CONTINUE READING
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