Taming of a Poison: Biosynthesis of the NiFe-Hydrogenase Cyanide Ligands

@article{Reissmann2003TamingOA,
  title={Taming of a Poison: Biosynthesis of the NiFe-Hydrogenase Cyanide Ligands},
  author={S. Reissmann and E. Hochleitner and Haofan Wang and A. Paschos and F. Lottspeich and R. Glass and A. B{\"o}ck},
  journal={Science},
  year={2003},
  volume={299},
  pages={1067 - 1070}
}
NiFe-hydrogenases have an Ni-Fe site in which the iron has one CO and two CN groups as ligands. Synthesis of the CN ligands requires the activity of two hydrogenase maturation proteins: HypF and HypE. HypF is a carbamoyltransferase that transfers the carbamoyl moiety of carbamoyladenylate to the COOH-terminal cysteine of HypE and thus forms an enzyme-thiocarbamate. HypE dehydrates theS-carbamoyl moiety in an adenosine triphosphate–dependent process to yield the enzyme thiocyanate. Chemical… Expand
Crystal structures of the carbamoylated and cyanated forms of HypE for [NiFe] hydrogenase maturation
[NiFe]-Hydrogenase Maturation.
The importance of iron in the biosynthesis and assembly of [NiFe]-hydrogenases
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