Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers
@article{Prakash2012TamingOF, title={Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers}, author={G. K. S. Prakash and P. V. Jog and P. T. D. Batamack and G. A. Olah}, journal={Science}, year={2012}, volume={338}, pages={1324 - 1327} }
CF3 from Fluoroform Fluoroform (CF3H) is a by-product from the manufacture of fluorocarbon-based materials used, for example, in nonstick coatings and refrigerants. Fluoroform's potency as a greenhouse gas is a growing concern as supplies continue to accumulate. In this context, Prakash et al. (p. 1324; see the Perspective by Haufe) show that fluoroform can be used to transfer CF3 to silicon, sulfur, and carbon centers in the development of CF3-bearing pharmaceutical and agrochemical structures… CONTINUE READING
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