Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers

@article{Prakash2012TamingOF,
  title={Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers},
  author={G. K. S. Prakash and P. V. Jog and P. T. D. Batamack and G. A. Olah},
  journal={Science},
  year={2012},
  volume={338},
  pages={1324 - 1327}
}
  • G. K. S. Prakash, P. V. Jog, +1 author G. A. Olah
  • Published 2012
  • Chemistry, Medicine
  • Science
  • CF3 from Fluoroform Fluoroform (CF3H) is a by-product from the manufacture of fluorocarbon-based materials used, for example, in nonstick coatings and refrigerants. Fluoroform's potency as a greenhouse gas is a growing concern as supplies continue to accumulate. In this context, Prakash et al. (p. 1324; see the Perspective by Haufe) show that fluoroform can be used to transfer CF3 to silicon, sulfur, and carbon centers in the development of CF3-bearing pharmaceutical and agrochemical structures… CONTINUE READING
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