Taming free energy landscapes with RNA chaperones.

@article{Woodson2010TamingFE,
  title={Taming free energy landscapes with RNA chaperones.},
  author={Sarah A Woodson},
  journal={RNA biology},
  year={2010},
  volume={7 6},
  pages={677-86}
}
Many non-coding RNAs fold into complex three-dimensional structures, yet the self-assembly of RNA structure is hampered by mispairing, weak tertiary interactions, electrostatic barriers, and the frequent requirement that the 5' and 3' ends of the transcript interact. This rugged free energy landscape for RNA folding means that some RNA molecules in a population rapidly form their native structure, while many others become kinetically trapped in misfolded conformations. Transient binding of RNA… CONTINUE READING

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