Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.

@article{Tamura2013Tam41IA,
  title={Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.},
  author={Yasushi Tamura and Yoshihiro Harada and Shuh-ichi Nishikawa and Koji Yamano and Megumi Kamiya and Takuya Shiota and Takuya Kuroda and Osamu Kuge and Hiromi Sesaki and Kenichiro Imai and Kentaro Tomii and Toshiya Endo},
  journal={Cell metabolism},
  year={2013},
  volume={17 5},
  pages={709-18}
}
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG from phosphatidic acid (PA) and CTP. However, we demonstrate here by using yeast Saccharomyces cerevisiae as a model organism that Cds1 resides in the ER but not in mitochondria, and that Tam41, a highly conserved… CONTINUE READING
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