Tam1, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference.

@article{Chua1997Tam1AT,
  title={Tam1, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference.},
  author={Penelope R Chua and G. Shirleen Roeder},
  journal={Genes & development},
  year={1997},
  volume={11 14},
  pages={1786-800}
}
The TAM1 gene of Saccharomyces cerevisiae is expressed specifically during meiosis and encodes a protein that localizes to the ends of meiotic chromosomes. In a tam1 null mutant, there is an increase in the frequency of chromosomes that fail to recombine and an associated increase in homolog nondisjunction at meiosis I. The tam1 mutant also displays an increased frequency of precocious separation of sister chromatids and a reduced efficiency of distributive disjunction. The defect in… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
65 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…