Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.

@article{Moulder1996TalinRB,
  title={Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.},
  author={Gary L Moulder and Minzhou Huang and Robert H. Waterston and Robert J. Barstead},
  journal={Molecular biology of the cell},
  year={1996},
  volume={7 8},
  pages={1181-93}
}
In cultured cells, the 230-kDa protein talin is found at discrete plasma membrane foci known as focal adhesions, sites that anchor the intracellular actin cytoskeleton to the extracellular matrix. The regulated assembly of focal adhesions influences the direction of cell migrations or the reorientation of cell shapes. Biochemical studies of talin have shown that it binds to the proteins integrin, vinculin, and actin in vitro. To understand the function of talin in vivo and to correlate its in… CONTINUE READING

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