Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

@inproceedings{Beaty2014TalinRM,
  title={Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis},
  author={Brian T. Beaty and Yarong Wang and Jose Javier Bravo-Cordero and Ved P Sharma and Veronika Miskolci and Louis Hodgson and John S Condeelis},
  booktitle={The Journal of cell biology},
  year={2014}
}
Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein talin in regulating these structures is not known. Here, we demonstrate that talin is required for invadopodial matrix degradation and three-dimensional extracellular matrix invasion in metastatic breast cancer cells. The sodium/hydrogen exchanger 1 (NHE-1) is linked to the cytoskeleton by ezrin/radixin/moesin… CONTINUE READING