Talin is required for integrin-mediated platelet function in hemostasis and thrombosis

  title={Talin is required for integrin-mediated platelet function in hemostasis and thrombosis},
  author={Brian G Petrich and Patrizia Marchese and Zaverio M. Ruggeri and Saskia Spiess and Rachel A.M. Weichert and Feng Ye and Ralph Tiedt and Radek C. Skoda and Susan J. Monkley and David R. Critchley and Mark H Ginsberg},
  journal={The Journal of Experimental Medicine},
  pages={3103 - 3111}
Integrins are critical for hemostasis and thrombosis because they mediate both platelet adhesion and aggregation. Talin is an integrin-binding cytoplasmic adaptor that is a central organizer of focal adhesions, and loss of talin phenocopies integrin deletion in Drosophila. Here, we have examined the role of talin in mammalian integrin function in vivo by selectively disrupting the talin1 gene in mouse platelet precursor megakaryocytes. Talin null megakaryocytes produced circulating platelets… CONTINUE READING
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