Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.

@article{Hyduk2011Talin1AK,
  title={Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.},
  author={Sharon J. Hyduk and Jacob Rullo and Adrianet Puig Cano and Haiyan Xiao and Mian Zhi Chen and Markus Moser and Myron I Cybulsky},
  journal={Journal of immunology},
  year={2011},
  volume={187 8},
  pages={4360-8}
}
Chemokine/chemoattractant G protein-coupled receptors trigger an inside-out signaling network that rapidly activates integrins, a key step in inflammatory leukocyte recruitment. Integrins mediate leukocyte arrest and adhesion to endothelium through multivalent binding, and they transmit outside-in signals to stabilize adhesion and coordinate cell spreading and migration. In the present study, we used RNA interference in the U937 monocytic cell line to investigate the role of talin-1, kindlin-3… CONTINUE READING

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