Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma.

  title={Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma.},
  author={Douglas B. Johnson and Igor J. Puzanov and Mark C. Kelley},
  volume={7 6},
Melanoma often spreads to cutaneous or subcutaneous sites that are amenable to direct, intralesional injection. As such, developing effective injectable agents has been of considerable interest. Talimogene laherperepvec (T-VEC) is an injectable modified oncolytic herpes virus being developed for the treatment of advanced melanoma. Pre-clinical studies have shown that T-VEC preferentially infects melanoma cells and exerts antitumor activity through directly mediating cell death and by augmenting… CONTINUE READING


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Abstract 2939: CAVATAK-mediated oncolytic immunotherapy in advanced melanoma patients

  • RH Andtbacka, DR Shafren, M Grose, L Post, J. Weisberg
  • Cancer Res
  • 2014

Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in Phase II study PV-10-MM-02

  • SS Agarwala, JF Thompson, BM Smithers, MI Ross, CR Scoggins
  • J. Clin. Oncol
  • 2014

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