Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.

@article{Amit2004TalAT,
  title={Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.},
  author={Ido Amit and Liat Yakir and Menachem Katz and Yaara Zwang and Mina D Marmor and Ami Citri and Keren Shtiegman and Iris Alroy and Shmuel Tuvia and Yuval Reiss and Eli Roubini and Maya M Cohen and Ron Wides and Eran Bacharach and Ullrich Schubert and Yosef Yarden},
  journal={Genes & development},
  year={2004},
  volume={18 14},
  pages={1737-52}
}
The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated ligase), whose RING finger is necessary for multiple monoubiquitylation of Tsg101. Bivalent binding of Tsg101 to a tandem tetrapeptide motif (PTAP) and to a central region of Tal is essential for Tal-mediated ubiquitylation of Tsg101. By studying endocytosis of the epidermal growth factor receptor and egress of the human immunodeficiency virus… CONTINUE READING