Taking stem cells to the clinic: Major challenges

  title={Taking stem cells to the clinic: Major challenges},
  author={Ariff Bongso and Chui-Yee Fong and Kalamegam Gauthaman},
  journal={Journal of Cellular Biochemistry},
Stem cell therapy offers tremendous promise in the treatment of many incurable diseases. A variety of stem cell types are being studied but human embryonic stem cells (hESCs) appear to be the most versatile as they are pluripotent and can theoretically differentiate into all the tissues of the human body via the three primordial germ layers and the male and female germ lines. Currently, hESCs have been successfully converted in vitro into functional insulin secreting islets, cardiomyocytes, and… 

The Therapeutic Potential, Challenges and Future Clinical Directions of Stem Cells from the Wharton’s Jelly of the Human Umbilical Cord

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Title : Establishing and optimizing feeder cell-free culture methods for human embryonic stem cells

Although both of the commercial feeder cell-free methods supported the undifferentiated growth of hESC, they both contained xeno-products and thus are not optimal methods for culturing hESCs, however, a functional feedercell-free method could ease the workload related to the preparation of feeder cells.

Immunogenicity and Immune-Modulating Properties of Human Stem Cells

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Derivation of human embryonic stem cells to study earlydevelopment and genetic disease

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