Taking race out of human genetics

@article{Yudell2016TakingRO,
  title={Taking race out of human genetics},
  author={Michael Yudell and Dorothy E. Roberts and Robert DeSalle and Sarah A. Tishkoff},
  journal={Science},
  year={2016},
  volume={351},
  pages={564 - 565}
}
Engaging a century-long debate about the role of race in science In the wake of the sequencing of the human genome in the early 2000s, genome pioneers and social scientists alike called for an end to the use of race as a variable in genetic research (1, 2). Unfortunately, by some measures, the use of race as a biological category has increased in the postgenomic age (3). Although inconsistent definition and use has been a chief problem with the race concept, it has historically been used as a… 
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References

SHOWING 1-10 OF 22 REFERENCES
Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century
Fatal Invention documents the emergence of a new biopolitics in the United States that relies on re-inventing race in biological terms using cutting-edge genomic science and biotechnologies. Some
The Standardization of Race and Ethnicity in Biomedical Science Editorials and UK Biobanks
TLDR
It is argued that, although a genetic concept of race and ethnicity is unlikely to wholly supplant a socio-political one, the adoption of census classifications into biomedical research is an alignment of state bureaucracy and science that could have significant consequences.
The importance of race and ethnic background in biomedical research and clinical practice.
TLDR
With the completion of a rough draft of the human genome, some have suggested that racial classification may not be useful for biomedical studies, since it reflects “a fairly small number of genes that describe appearance” and “there is no basis in the genetic code for race.
Genes, race and research ethics: who’s minding the store?
TLDR
Given the general vagueness and imprecision among these researchers regarding their use of these variables, they do not seem well equipped for such an undertaking, it would seem imperative that research ethicist move forward to develop specific policies and practices to assure the scientific integrity of genetic research on biological differences between population groups.
Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
TLDR
The parent–child pairs revealed a trend toward increasing exogamy over time; the presence in the cohort of individuals endorsing multiple race/ethnicity categories creates interesting challenges and future opportunities for genetic epidemiologic studies.
Evidence for gradients of human genetic diversity within and among continents.
TLDR
The results show that when individuals are sampled homogeneously from around the globe, the pattern seen is one of gradients of allele frequencies that extend over the entire world, rather than discrete clusters, and there is no reason to assume that major genetic discontinuities exist between different continents or "races".
Individual Genomes Instead of Race for Personalized Medicine
TLDR
This work examines six drug‐metabolizing genes in J. Craig Venter and James Watson, two Caucasian men whose genomes were recently sequenced, and underscores the importance of personalized genomics over a race‐based approach to medicine.
Population description and its role in the interpretation of genetic association
TLDR
Care with population description, while important, may not fully address analytical concerns concerning the interpretation of variable study outcomes or ethical concerns regarding the attribution of genetic observations to broad social groups, and criteria which help investigators better distinguish justified and unjustified forms of population generalization may be required.
Commentary: considerations for use of racial/ethnic classification in etiologic research.
TLDR
These suggested guidelines address issues of variable definition, study design, and covariate control, providing a consistent foundation for etiologic research programs that neither ignore racial/ethnic disease disparities nor obfuscate the nature of these disparities through inappropriate analytical approaches.
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