Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology

@article{Cox2004TakingIT,
  title={Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology},
  author={T. Cox},
  journal={Clinical Genetics},
  year={2004},
  volume={65}
}
  • T. Cox
  • Published 2004
  • Biology, Medicine
  • Clinical Genetics
The rapid proliferative expansion and complex morphogenetic events that coordinate the development of the face underpin the sensitivity of this structure to genetic and environmental insult and provide an explanation for the high incidence of midfacial malformation. Most notable of these malformations is cleft lip with or without cleft palate (CLP) that, with an incidence of between one in 600 and one in 1000 live births, is the fourth most common congenital disorder in humans. Despite the… Expand
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References

SHOWING 1-10 OF 93 REFERENCES
Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head
Bmp4 gene is expressed at the putative site of fusion in the midfacial region.
  • S. Gong, Chiao Guo
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 2003
The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis.
A zone of frontonasal ectoderm regulates patterning and growth in the face
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.
Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development.
Recent advances in primary palate and midface morphogenesis research.
  • V. Diewert, K. Y. Wang
  • Biology, Medicine
  • Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1992
...
1
2
3
4
5
...