Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology

  title={Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology},
  author={TC Cox},
  journal={Clinical Genetics},
  • TC Cox
  • Published 1 March 2004
  • Biology
  • Clinical Genetics
The rapid proliferative expansion and complex morphogenetic events that coordinate the development of the face underpin the sensitivity of this structure to genetic and environmental insult and provide an explanation for the high incidence of midfacial malformation. Most notable of these malformations is cleft lip with or without cleft palate (CLP) that, with an incidence of between one in 600 and one in 1000 live births, is the fourth most common congenital disorder in humans. Despite the… 

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  • V. DiewertK. Y. Wang
  • Medicine
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1992
Analysis of human embryos in the Carnegie Embryology Collection and mouse embryos of cleft lip and noncleft strains showed that human andmouse embryos have similar phases of primary palate development: first, an epithelial seam, the nasal fin, forms; then a mesenchymal bridge develops through the nasalFin and enlarges rapidly.