Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology

@article{Cox2004TakingIT,
  title={Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology},
  author={TC Cox},
  journal={Clinical Genetics},
  year={2004},
  volume={65}
}
  • TC Cox
  • Published 1 March 2004
  • Biology
  • Clinical Genetics
The rapid proliferative expansion and complex morphogenetic events that coordinate the development of the face underpin the sensitivity of this structure to genetic and environmental insult and provide an explanation for the high incidence of midfacial malformation. Most notable of these malformations is cleft lip with or without cleft palate (CLP) that, with an incidence of between one in 600 and one in 1000 live births, is the fourth most common congenital disorder in humans. Despite the… 

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