Taking charge of proteins from neurodegeneration to industrial biotechnology.

@article{Shaw2010TakingCO,
  title={Taking charge of proteins from neurodegeneration to industrial biotechnology.},
  author={Bryan F Shaw and Demetri T. Moustakas and Julian P Whitelegge and Kym F. Faull},
  journal={Advances in protein chemistry and structural biology},
  year={2010},
  volume={79},
  pages={
          127-64
        }
}
The aggregation and precipitation of a soluble protein-within a motor neuron, or a pharmaceutical vial, or even inside a industrial-scale hydrolysis chamber-is a problem in human health and in biotechnology. A growing body of research is suggesting that the magnitude of the net charge of a protein is a determinant of the rate at which proteins self-assemble in solution into aggregates with amorphous or fibrillar (or uncharacterized) morphologies. This chapter discusses how this apparently… CONTINUE READING

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