Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions.

@article{Kabir2010TakingAR,
  title={Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions.},
  author={Shaheen Kabir and Agnel Sfeir and Titia de Lange},
  journal={Cell cycle},
  year={2010},
  volume={9 20},
  pages={4061-7}
}
Mammalian Rap1, a TRF2-interacting protein in the telomeric shelterin complex, was recently shown to repress homology-directed repair at chromosome ends. In addition, Rap1 plays a role in transcriptional regulation and NFκB signaling. Rap1 is unique among the components of shelterin in that it is conserved in budding yeast and has non-telomeric functions. Comparison of mammalian Rap1 to the Rap1 proteins of several budding yeasts and fission yeast reveal both striking similarities and notable… CONTINUE READING

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