Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.

@article{Anderson2009TakingAH,
  title={Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.},
  author={Shannon M. Anderson and A Abd el Raouf Khalil and Mohamed Uduman and Uri Hershberg and Yoram Louzoun and Ann M. Haberman and Steven H. Kleinstein and Mark J. Shlomchik},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={7314-25}
}
B lymphocytes producing high-affinity Abs are critical for protection from extracellular pathogens, such as bacteria and parasites. The process by which high-affinity B cells are selected during the immune response has never been elucidated. Although it has been shown that high-affinity cells directly outcompete low-affinity cells in the germinal center (GC), whether there are also intrinsic differences between these cells has not been addressed. It could be that higher affinity cells… CONTINUE READING

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