Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

@inproceedings{Capsoni2011TakingPO,
  title={Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked
                    to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic
                    Activity},
  author={Simona Capsoni and Sonia Covaceuszach and S. Marinelli and Marcello Ceci and Antonietta Bernardo and Luisa Minghetti and Gabriele Ugolini and Flaminia Pavone and Antonino Cattaneo},
  booktitle={PloS one},
  year={2011}
}
During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors, thereby increasing the response to noxious stimuli. The relationship between NGF and pain is supported by genetic evidence: mutations in the NGF TrkA receptor in patients affected by an hereditary rare disease (Hereditary Sensory and Autonomic Neuropathy type IV, HSAN IV) determine a congenital form of severe pain insensitivity, with mental retardation, while a mutation in NGFB gene, leading to the aminoacid… CONTINUE READING