Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells.

@article{eco2003TaipoxinIF,
  title={Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells.},
  author={Patricia {\~N}eco and Ornella Rossetto and A. Luisa Gil and Cesare Montecucco and Luis M. Gut{\'i}errez},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 2},
  pages={329-37}
}
Adrenomedullary bovine chromaffin cells were used to study the uptake and cellular effects of the phospholipase type A2 (PLA2) neurotoxin taipoxin in a neuroendocrine model. This toxin entered rapidly inside cultured cells. Within 1 h, taipoxin accumulated on the plasma membrane, independently of calcium presence, and caused fragmentation of the F-actin cytoskeleton. Toxin-induced cell death occurred after 24 h of incubation with the appearance of toxin containing large vesicles. Secretory… CONTINUE READING